The six brain‐specific TAU isoforms and their role in Alzheimer's disease and related neurodegenerative dementia syndromes
6 Citations•2024•
Sarah Buchholz, H. Zempel
Alzheimer's & Dementia
Alternative splicing of the human MAPT gene generates six brain‐specific TAU isoforms, which can lead to neurodegenerative diseases and highlight the need for precise control over TAU isoform balance.
Abstract
Alternative splicing of the human MAPT gene generates six brain‐specific TAU isoforms. Imbalances in the TAU isoform ratio can lead to neurodegenerative diseases, underscoring the need for precise control over TAU isoform balance. Tauopathies, characterized by intracellular aggregates of hyperphosphorylated TAU, exhibit extensive neurodegeneration and can be classified by the TAU isoforms present in pathological accumulations.