Partial agonists of dopamine receptors: receptor theory and the dopamine hypothesis of psychosis
4 Citations•2021•
J. Cookson, J. Pimm
BJPsych Advances
D dopamine partial agonism is discussed, which is the main mechanism of action of the psychiatric drugs aripiprazole, brexpiprazoles and cariprazine and the dopamine hypothesis of psychosis and the role of dopamine and serotonin in depression is summarized.
Abstract
SUMMARY This article discusses dopamine partial agonism, which is the main mechanism of action of the psychiatric drugs aripiprazole, brexpiprazole and cariprazine. It outlines the principles of receptor theory and the structure of dopamine receptors; characterises agonists, antagonists and partial agonists; and summarises the dopamine hypothesis of psychosis and the role of dopamine and serotonin in depression.