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This chapter reviews the contributions of the Global Early Adolescent Study (GEAS), a multi-national longitudinal study of disadvantaged urban populations, beginning in the critical early adolescent period.We highlight tools developed to capture gendered dynamics among adolescents, including empowerment and perceptions of gender norms. Initial data collected for the GEAS have contributed to several cross-national findings about adolescent well-being to date. The chapter also outlines the GEAS global research network’s experiences and challenges implementing longitudinal survey research with vulnerable young populations, including cross-cultural ethical issues and participant retention. Finally, we describe how data collected for the GEAS can contribute to the enrichment of policy indicators for vulnerable adolescent populations globally.