Diagnosis and treatment of Alzheimer's disease and other neurodegenerative diseases causing dementia
An isolated monoclonal anti-human amyloid beta or a fragment thereof comprising a complete set of six CDRs, three CDRs of the variable region of the heavy chain (VH) having the amino acid sequences of SEQ ID NO: 15 23 and 29.
Abstract
An isolated monoclonal anti-human amyloid beta or a fragment thereof comprising a complete set of six CDRs, three CDRs of the variable region of the heavy chain (VH) having the amino acid sequences of SEQ ID NO: 15 23 and 29, and three CDRs of the variable region of the light chain (VL) having the amino acid sequences of SEQ ID NO: 33, 41 and 45; or the amino acid sequence of the variable region of the light chain (VL) and the amino acid sequence of the variable region of the heavy chain (VH) of SEQ ID NO: 53 and SEQ ID NO: 60, SEQ ID # 145 and SEQ ID NO: 60, SEQ ID NO 51 and SEQ ID NO: 60, SEQ ID NO 52 and SEQ ID NO: 60, SEQ ID NO 146 and SEQ ID N .o 60, SEQ ID NO 53 and SEQ ID NO: 148, SEQ ID NO 55 and SEQ ID NO: 61, SEQ ID NO 54 and SEQ ID NO: 61, or SEQ ID N .o 146 and SEQ ID NO: 61, respectively.