Striatal Dopamine Loss in Early Parkinson's Disease: Systematic Review and Novel Analysis of Dopamine Transporter Imaging
11 Citations•2023•
N. Heng, N. Malek, M. Lawton
Movement Disorders Clinical Practice
Functional neuroimaging can be applied in larger numbers during life, which allows analysis of the extent of dopamine loss more directly, and helps clarify the cause of Parkinson's disease symptoms.
Abstract
Neuropathological studies, based on small samples, suggest that symptoms of Parkinson's disease (PD) emerge when dopamine/nigrostriatal loss is around 50–80%. Functional neuroimaging can be applied in larger numbers during life, which allows analysis of the extent of dopamine loss more directly.