Dr. Samuel Hahnemann had an epiphany after he took a dose of cinchona bark and developed symptoms similar to those of malaria, which led to his second law of homeopathy, the law of infinitesimals, which states that dilution increases the potency of a remedy.
In 1800, conventional medicine was a disaster. Doctors weakened patients with bloodletting and purging, they poisoned them with mercury and other harmful substances, and they often killed more patients than they cured. Dr. Samuel Hahnemann was looking for safer, more effective ways to help his patients. He had an epiphany after he took a dose of cinchona bark and developed symptoms similar to those of malaria, the disease cinchona was supposed to treat. He extrapolated from this one observation to conclude that if any substance causes a symptom in healthy people it can be used to treat the same symptom in sick people. He formulated this as the first law of homeopathy, similia similibus curentur, usually translated as “like cures like.” He diluted his remedies so that they would no longer cause symptoms; this led to his second law of homeopathy, the law of infinitesimals, which states that dilution increases the potency of a remedy. When he observed that his remedies worked better during house calls than in his office, he attributed it to jostling in his saddle bags, so he added the requirement of “succussion,” specifying that remedies must be vigorously shaken (not stirred) by striking them against a leather surface at every step of dilution.