Top Research Papers on Alzheimer's Disease

The goal of Enroll-HD is to build a large and rich database of clinical information and biospecimens that will serve as a basis for future studies aimed at developing tools and biomarkers for progression and prognosis.

The Alzbioindigo Consortium held its 3rd workshop in Jaipur and Udaipur, India, from February 12 to 16, 2012, to intensify collaboration in the field of AD related research.

A growing body of research unequivocally establishing a link between the cerebellum and AD, other forms of dementia, and other NDs is revealed, supported by clinical evidence, pathological and biochemical profiles, structural and functional neuroimaging data, and electrophysiological findings.

An isolated monoclonal anti-human amyloid beta or a fragment thereof comprising a complete set of six CDRs, three CDRs of the variable region of the heavy chain (VH) having the amino acid sequences of SEQ ID NO: 15 23 and 29.

The joint change of separate component oxidative stress with the degree of mental disorders is shown and the high activity of superoxide dismutase in patients with Alzheimer's disease has been discovered.

The joint change of separate component oxidative stress with the degree of mental disorders is shown and the high activity of superoxide dismutase in patients with Alzheimer's disease has been discovered.

Increased awareness of the potential causes of sleep disturbance can lead to improved treatment strategies yielding benefits for both patient and care-giver.

The key imaging biomarkers from MR imaging, 18F-FDG PET, and amyloid PET; the imaging features of the most common neurodegenerative dementias; the role of various neuroimaging studies in differential diagnosis and prognosis; and some promising imaging techniques under development are discussed.

This review focuses on tau mutations, phosphorylation sites, tau isoforms and the neurohistopathology of AD, and three other tauopathies to demonstrate that disease progression and neuronal loss in AD correlate also with pathological tau and not just amyloid deposition.

Unequivocally characterized by a vast etiology, AD is a multifactorial disorder resulting from the bilateral interaction and continuous corroboration of genetic and environmental factors.

Dementia is a term used to describe the deterioration of cognitive function beyond what would be expected because of natural biological aging.

A review of the major findings of functional connectivity assessed by resting state fMRI in Alzheimer's disease and frontotemporal dementia reveals relationships between brain regions or brain networks that may be particularly susceptible to dysfunction.

This work examined the pathogenesis of prion and AD with a focus on the contribution of PrPC to the development of AD and analyzed the mechanisms that lead to the formation of a high affinity bond between Aβ oligomers (AβOs) and PrPC.

P21-1 Altered trace elemental homeostasis in neurodegenerative (Alzheimer’s and Parkinson’s) and neuropsychiatric (bipolar) disorder P. Shanmugavelu,* T. S. Sathyanarayana Rao, M. L. Hegde, M.S. Mustak, R. B. Menon,* R. V. Rao* and K. S. Jagannatha Rao *Analytical Control Section, Bhabha Atomic Research Centre, Mumbai; Department of Psychiatry, J.S.S. Medical College and Hospital, Mysore; Department of Biochemistry and Nutrition, Central Food Technological Research Institute, Mysore, India

It is observed excitotoxicity, predisposing to ischemic stroke, activation of neuroinflammation, excessive production of Beta-Amyloid Protein and aberrantly phosphorylated tau,activation of astrocytes evidenced by overexpression of Glial Fibrillar Acid Protein and decrease on expression of Brain-Derived Neurotrophic Factor (BDNF).

Probabilistic gravity is extended to medical and engineering issues, while addressing the Clay mathematics institute’s problem about Navier-Stokes Equation on their web site.

This finding suggests that vascular pathology plays a crucial role in the pathogenesis of so-called neurodegenerative dementias, and a better understanding of their pathogenesis and improved therapeutic strategies is certainly warranted.

The neurocognitive and behavioral profiles of vascular dementia and vascular cognitive impairment, dementia with Lewy bodies and Parkinson's disease with dementia, and dementia syndromes associated with frontotemporal lobar degenerations are compared and contrasted with Alzheimer's dementia.

Eastern Carolina Chapter of the Society for Neuroscience presents David L. McKinzie, PhD Senior Research Advisor Eli Lilly and Company for the second year in a row on central giant cell apoptosis and cell reprograming.

This chapter describes Alzheimer's as well as other major neurodegenerative conditions to demonstrate both similarities and differences.

Findings from human and non-human studies examining the association of metformin with AD/ADRD related outcomes suggest that met formin use in persons with T2D is associated with a lower risk of dementia.

Oxidative stress and additional free radical generation catalyzed by the redox metals play important role in the neuro-degeneration and Mitochondrial dysfunctions and excitotoxicity result into the pathological conditions in each disease.

This thesis will review the current research on disease etiology, diagnostic tools, risk factors and treatment of Alzheimer's disease.

W artykule zostały przedstawione podstawowe mechanizmy leżące u podłoża obu schorzeń standardy leczenia oraz kierunki poszukiwań nowych metod terapeutycznych.

Evidence showing that mitochondrial dysfunction and oxidative stress are intimately involved in AD pathophysiology is discussed, with strong indications that oxidative stress occurs prior to the onset of symptoms in AD.

It is important to understand functional differences between dementia and non‐dementia of AD to predict progression forward to dementia at prodromal or preclinical stage of AD.

The current landscape of SV analysis in AD and SVs that have been found associated with AD were reviewed and the importance of currently less explored SVs, including insertions, inversions, short tandem repeats, and transposable elements in neurodegenerative diseases were highlighted.

Human beings use all sensory organs in biological/physiological, neurological/functional ways to feed the brain/brain cells with necessary input/impulses of all environment information for the brain. Practical review: Our lifestyle, ‐losing anymore in life emotional our reactions are: fear, stress, panic, aggressive, depressive, affected person withdraws him/herself: forgets daily life structures/real‐world, loses relationships of any kind , falls backwards in development stages.

The CHARIOT register was designed specifically to support recruitment into observational natural history studies of pre-symptomatic or prodromal dementia stages, and primary or secondary prevention pharmaceutical trials or other prevention strategies for dementia and other cognitive problems associated with ageing.

The drugs currently available and future theories for the development of new treatments for AD are described, including Disease-Modifying Therapies (DMTs), chaperones, and natural products.

Alternative splicing of the human MAPT gene generates six brain‐specific TAU isoforms, which can lead to neurodegenerative diseases and highlight the need for precise control over TAU isoform balance.

This work aimed to compare and identify pathways associated with hypometabolism‐based and atrophy‐based subtypes in Alzheimer’s disease.

It is suggested that the functional and structural plasticity changes of the PSD may contribute to the loss of molecular homeostasis within the synapse (and contribute to early symptoms) in these dementias.

The potential role of DBS for the treatment of dementia symptoms in AD and PDD is explored and the latest research results from Gratwicke et al. (2017) are included to compare them with the results of previous relevant studies.

There are almost 40 million people aged 65+ in the United States and the population of persons 85+ is projected to increase from 4.2 million in the year 2000 to 6.6 million inThe year 2020, which suggests that these neurodegenerative diseases will reach a prevalence of epidemic proportions.

Role of drosophila in the study of each type has been discussed, with respect to different manipulations done in the organism, and different model organisms used to study various neurodegenerative diseases were tabulated.

This study supports going beyond disease diagnosis when examining caregiver experiences and organized caregivers across disease diagnosis into clusters with similar symptom presentation, care demands, support, and QoL.

The similarities and differences between AD and post stroke cognitive impairment (PSCI) in neuroimaging changes, disease progression, and multiple omics studies are studied to study the contribution of vascular factors to dementia pathogenesis.

The most common neurodegenerative disease (Alzheimer's and Huntington disease) will be discussed and experimental models designed to investigate the pathogenesis, diagnosis and treatment options of neurodegnerative diseases will be discuss.

The role of the cerebellum in dementia and neurodegenerative diseases is studied using a probabilistic approach and the results suggest that the former is more predictive of dementia than the latter.

Recommendations conceptualize TBI as a contributor to MED and emphasize the unique opportunity to study AD/ADRD following known exposure to inform disease mechanisms and treatment targets for shared common AD/ ADRD pathways.

Emotion recognition measurement had added value for differentiation between patients first visiting memory clinics, in particular in distinguishing Dementia‐AD from MCI.

Individuals with other forms of dementia may exhibit some of the same signs and symptoms as those with AD, including vascular dementia and dementia due to chronic alcoholism.

Inhibition of ROS and NO overproduction as well as endogenic regulation of cytokine induction could be of therapeutic importance and delay neurodegeneration in AD.

To examine the associations between the allergic triad (asthma, allergic rhinitis, atopic dermatitis) and risk of dementia, a large number of studies have found links between the three conditions and dementia.

Neuropsychological data are key to progress in understanding and developing more effective treatments for Alzheimer's disease and other dementia, and efforts to identify early markers of dementia will be a key component to development of early intervention strategies.

Clioquinol, a copper chelator that may prevent copper and zinc from binding the beta amyloid, was recently found to have beneficial effects on slowing deterioration in AD and suggest potentially new avenues for clinical research.

This repository has a significant (and increasing) sample size consisting of a wide range of neurodegenerative disorders and employs advanced imaging protocols and MRI-guided histopathological analysis to help disentangle the effects of comorbid disorders to refine diagnosis, prognosis and better understand neurodegenerative disorders.

In the last 20 years, research focused on developing retinal imaging as a source of potential biomarkers for Alzheimer's disease and other neurodegenerative diseases, has increased significantly. The Alzheimer's Association and the Alzheimer's & Dementia: Diagnosis, Assessment, Disease Monitoring editorial team (companion journal to Alzheimer's & Dementia) convened an interdisciplinary discussion in 2019 to identify a path to expedite the development of retinal biomarkers capable of identifying biological changes associated with AD, and for tracking progression of disease severity over time. A...

The identification of adequate nutritional interventions and the not yet fully understood nutrient activity in AD could be the next steps in finding several innovative treatment options for neurodegenerative disorders, as Nutritional Psychiatry is currently gaining relevance in neuropsychiatric disease treatment.