Top Research Papers on Dopamine

The most common off-targets for established dopamine receptor ligands are given and an outline of molecules sufficiently specific for one or more subtypes, the presence of DR, α2-ARs, and 5-HT receptors in CNS areas, which could help avoid ambiguous results.

If ten years ago the use of natural dopamine receptors on cell membranes seemed impossible for biosensors, the actual technology allows co-integrate transistors and vesicles with natural receptors of dopamine, like G protein-coupled receptors, and the uni-molecular detection selectivity is promising.

This review comprehensively assesses the current knowledge of dopaminergic immunomodulation and the role of dopamine in disease pathogenesis at the cellular and tissue level and prompts the development of therapeutics and strategies targeted toward ameliorating disease through dopamine regulation of immunity.

Evidence for heterogeneity within the mesoaccumbal DA system is evaluated and it is argued that frameworks of DA function must incorporate the precise topographic organization of VTA DA neurons to clarify their contribution to health and disease.

This review article highlights recent advances that have demonstrated the crucial role DA plays in mediating different phases of fear extinction, including the formation of extinction memories.

A label-free SERS approach for DA detection was explored, employing two conventional methods to synthesize Ag colloids and a novel approach for synthesis of AgNP-PDA composites, which allowed for the formation of stable PDA complexes with AgNPs.

The evidence indicates that impaired dopamine release can result from disruption to a diverse range of Parkinson’s disease-associated genetic and molecular disturbances, and can be considered as a potential pathophysiological hallmark of Parkinson's disease.

Show that the subpopulation of midbrain dopaminergic neurons that express the vesicular glutamate transporter 2 (VGLUT2) are more resilient to rotenone-induced neurodegeneration, and this finding offers a putative new target for neuronal resilience that can be manipulated to prevent toxicant-induced DA neurodegenersation in PD.

D dopamine plays a main role in the reward system with regard to obesity, and the association of DR availability with BMI was dependent on radiopharmaceuticals, while DAT availability did not show the significant relationship with BMI regardless of radiophARMaceuticals.

Psychosis is one of the psychiatric disorders that is controlled by dopaminergic drugs such as antipsychotics that have affinity for the dopamine D2 receptor (DRD2). In this investigation we perform quantum chemical calculations of two molecules [dopamine and risperidone] within a large cavity of DRD2 that represents the binding site of the receptor. Dopamine is an endogenous neurotransmitter and risperidone is a second-generation antipsychotic. Non-covalent interactions of dopamine and risperidone with DRD2 are analyzed using the Quantum Theory of Atoms in Molecules (QTAIM) and the Non-Covale...

These studies show broad dissociation in the fundamental prediction and reward-related information generated by different dopamine neuron populations and signaled by dopamine across the striatum, and offer new insight into how larger-scale plasticity across the striatal network emerges during Pavlovian learning to coordinate behavior.

It is shown that dopamine increases protein synthesis in mouse hippocampal CA1 neurons, enabling dopamine-dependent long-term potentiation (DA-LTP), which is mediated via the Ca2+-sensitive adenylate cyclase (AC) subtypes 1/8, cAMP, and cAMP-dependent protein kinase (PKA).

It is confirmed that the tail striatum is not only a distinct dopamine domain but also that each tail division has unique dopamine transmission characteristics, which supports that the divisions are not only anatomically but also functionally distinct.

The research needs in order to understand dopamine receptors in the heart better are defined, and an update on the role of dopamine receptor in the human heart appears to be clinically relevant.

Evidence is presented that DA neuron VGLUT2 expression may be neuroprotective, boosting DA neuron resilience in the context of ongoing neurodegenerative processes in PD, and potential Neuroprotective mechanisms are discussed.

Using functional imaging on the Caenorhabditis elegans model system, it is shown that DAT‐1 acts as a negative feedback modulator to neurotransmitter vesicle fusion, and a mechanistic model is developed to dissect the dynamics of synaptic vesicles fusion.

This work proposes dopamine as a model not only of neurotransmission but also of neuromodulation capable of modifying neuronal architecture and describes how modifications lead to synaptic plasticity and finally to morphological and functional changes, starting from maladaptive neuro-modulation and ending in neurodegeneration.

The materials (metals and metal oxides, carbon materials, polymers) that are frequently used for the electrochemical biosensing of dopamine and point out their respective advantages and drawbacks are reviewed.

DAT mRNA mapping may have only limited predictive power for DAT availability in humans, however, the difference in distribution of DAT mRNA and DAT protein may influence this limitation.

Preliminary evidence for a potential role of dopamine to act as a paracrine messenger in the gastrointestinal mucosa and endocrine pancreas of horses is provided.

D dopamine partial agonism is discussed, which is the main mechanism of action of the psychiatric drugs aripiprazole, brexpiprazoles and cariprazine and the dopamine hypothesis of psychosis and the role of dopamine and serotonin in depression is summarized.

Functional neuroimaging can be applied in larger numbers during life, which allows analysis of the extent of dopamine loss more directly, and helps clarify the cause of Parkinson's disease symptoms.

This review article mainly focuses on the cell types, neurotransmitters, neuropeptides, ion channels, receptors, and neural circuits of the VTA dopamine system, with the hope of obtaining new insight into the formation and function of this vital brain region.

A theoretical basis for drug development targeting DA receptors in inflammatory diseases is provided, with detailed descriptions of their roles in Parkinson disease, inflammatory bowel disease, rheumatoid arthritis, systemic lupus erythematosus, and multiple sclerosis.

Histological findings in a 64-year-old woman with an adrenal incidentaloma give a possible hypothesis that the mechanism underlying a dopamine-secreting pheochromocytoma is associated with immature catecholamine vesicles in which dopamine β-hydroxylase is localized, thus resulting in inhibited conversion from dopamine to norepinephrine.

An algorithm for retrospective causal learning was developed and it was found that mesolimbic dopamine release conveys causal associations but not RPE, thereby challenging the dominant theory of reward learning.

The hypothesis has formed a useful drug discovery paradigm to the extent that all currently approved treatments can be considered to conform to a dopaminergic view of schizophrenia/antipsychotic drug action.

Recent advances from animal models in understanding how dopamine controls relapse to drug seeking are reviewed and the need to better understand when, where and how dopamine contributes to relapse behaviours is highlighted.

This review is focused on how dopamine is synthesized in organs and tissues and the mechanisms by which dopamine and its receptors exert their effects on the inflammatory response.

The findings provide the first anatomical and functional evidence supporting an important role of PPARa/g in DA-dependent behavior and cannabinoid action and help clarify the role of these receptors in cannabinoid action.

It is found that DGKη knockout markedly increased dopamine levels in the midbrain and cerebral cortex and significantly augmented phosphorylated DA transporter (DAT) levels, which induce DA efflux to the synaptic cleft, in the cerebral cortex.

The current state of D1R drug development is addressed, including the pharmacology of newly developed non-catecholamine ligands, and the potential utility of D 1R-agonists in Parkinson's Disease and cognitive impairment is discussed.

A dual-nanopore biosensor utilizing a DNA aptamer probe to specifically interact with dopamine, enabling detection of intracellular dopamine and dopamine efflux (extracellular dopamine) in a single pheochromocytoma (PC12) cell is reported.

This review explores the promising outcomes observed with estradiol and estrogen receptor agonists administration in both gonadectomized and/or genetically knockout rodents, suggesting potential therapeutic avenues and contributes to advancing the field.

The neurotransmitter dopamine (DA) is generally associated with Parkinson's disease (PD) [...].

The present review does not deal with schizophrenia but, rather, with the historical development of the current understanding of the dopamine-associated actions of the drugs that reduce the symptoms of psychosis.

Two ion channels, Kv4.3 and BKCa1.1, regulate the pattern of dopamine neuron firing and dopamine release on different time scales to influence separate phases of reinforced behavior in mice, demonstrating that disruption of intrinsic regulators of neuronal activity differentially affects dopamine dynamics during reinforcement and extinction learning.

D dopamine receptors expressed in the brain are decreased, thereby reducing interest in activities not already stamped in by habitual rewards, and most addictive drugs cause elevations in extracellular levels of the neurotransmitter dopamine.

Cabergoline, as a dopamine receptor agonist, emerges as a valuable therapeutic option for hyperprolactinemia, Parkinson's disease, and restless legs syndrome and shows potential for improving patients' quality of life.

It is reported that Epac2 in the mesolimbic dopamine system promotes cocaine reinforcement via enhancement of dopamine release via chemogenetic activation of ventral tegmental area dopamine neurons and reversed the impairment of cocaine self-administration inEpac2-cKO mice.

The pivotal function of dopamine neurons in familiarity is highlighted and a role in modulating the salience of memory content is suggested, mirroring the effects of multiple familiarization sessions.

ABSTRACT Dry and hot/wet lap shear specimens were prepared and tested to evaluate catechol-containing additives in a model epoxy adhesive. We specifically compared adding neutral dopamine, which is capable of being covalently incorporated into the epoxy network, with molecular analogues that contain methyl, methoxy and fluorine rather than hydroxyl groups. We found that catechol was unique among these additives in improving both dry and hot/wet lap shear strength. While neutral dopamine can only be added to relatively low concentrations due to solubility limitations, other catechol-containing ...

Ketamine strengthens connections between two brain regions that are involved in the production and regulation of dopamine, which may explain how the drug can alleviate depression.

The neurobiological mechanisms that underlie dopamine-dependent auditory hallucinatory states, with therapeutic implications, are uncovered by Schmack et al. (5).

While the repurposing of oncology drugs based on dopamine signaling is promising, further studies are still needed to fully understand the mechanisms involved and determine the clinical efficacy and safety of these approaches.

The versatility behind the cholinergic neurotransmission modulation through the activation of M1 and M4 receptors, exemplified by the prospective drug candidate KarXT, is described and the latest advancements in developing novel solutions to the complex challenges posed by schizophrenia are presented.

This review presents an original study describing the discovery of a new regulatory mechanism for neurometabolic physiological function in humans and animals, a key part of this mechanism is the dopamine–aminotransferase system.

The relationship of oxytocin with several components of the dopaminergic system, gamma-aminobutyric acid (GABA) inhibitory neurotransmission and their alterations in the autism spectrum disorder is discussed.

A rational design of high-efficiency electrocatalysts and thus achieving sensitive electrochemical sensing remains a great challenge. In this work, single-atom indium anchored on nitrogen-doped carbon (In1-N-C) with an In-N4 configuration is prepared successfully through a high-temperature annealing strategy; the product can serve as an advanced electrocatalyst for sensitive electrochemical sensing of dopamine (DA). Compared with In nanoparticle catalysts, In1-N-C exhibits high catalytic performance for DA oxidation. The theoretical calculation reveals that In1-N-C has high adsorption energy f...

Evidence suggesting that midbrain dopaminergic neurons signal reward prediction error, driving synaptic plasticity in the striatum underlying learning is reviewed, finding it seems likely that dopamine signals in the Striatum might underlie important aspects of goal-directed reward-based learning.