Top Research Papers on Heterocyclic Compounds PDF

the chemistry of heterocyclic compounds are a good way to achieve details about operating certainproducts. Many products that you buy can be obtained using instruction manuals. These user guides are clearlybuilt to give step-by-step information about how you ought to go ahead in operating certain equipments. Ahandbook is really a user's guide to operating the equipments. Should you loose your best guide or even the productwould not provide an instructions, you can easily obtain one on the net. You can search for the manual of yourchoice online. Here, it is possible to work with google to brows...

The present application provides compounds of formula (I) that modulate the activity of stearoyl-CoA desaturase and pharmaceutical compositions comprising such derivatives.

This first of its kind Ukrainian manual on the chemistry of heterocyclic compounds sets out the basics of the chemistry of heterocyclic compounds: the most important classes, methods of synthesis, physicochemical properties and chemical reactions. For the first time in the manual on the chemistry of heterocyclic compounds, the problem of the cyclic state of a chemical substance is outlined, separate sections are devoted to ionic, radical and carbene states of these substances. For students of chemical specialties of universities, as well as graduate students, teachers and researchers.

複 素環化合物 は,そ の特異 な反応性,生 理活性 などの ために,広 く有機化学者 の興味 をひ くところで あった。 他 方,近 年含 フ ッ素複素芳香環 化合物 の合成 も種 々行な われ,興 味あ る反応 性を示す ことが明 らかに されつつあ る。 本総説で はそ の 中 か らペル フルオル アル キル(以 下 Rfと 略)基 を有 する複 素芳香環化 合物 の反 応性 に焦点 を合 わせてみるこ とにす る。す なわち,Rf基 は従来非 常 に安 定な置換基 とされ,た とえばベ ンゾ トリフル オラ イ ド(以下BTFと 略)の トリフルオル メチル(以 下CF3 と略)基 はほ とん どの試薬 と反応 しない 安定な置換基 と されていたが,こ れが複 素環上 にある と種 々の試薬 に対 して特異な反応 をするばか りでな く,光 反応 においても 興味あ る生成 物を与え ることが,筆 者 らの研究に よ り明 らかにな った。 なお芳香族 フ ッ素化合物の合成 と反応全般 については 約2年 前 の本誌1)に まとめた ので,そ れ を参照 していた だ くこ ととして,合 成法 につい てはそれ以後 の新 しい例 を付 け加 えるに とどめた。 しか し反応性 につい ては話 の 都 合上一部重複 するほか,詳 細 な記述 が必要 とな り,そ の点で全...

公开了一种由式1A表示的杂环化合物和一种包括该杂环化合物的有机发光装置：式1AR1至R13中的至少一个是由下面的式1B表示的基团：式1B其中，R1至R15、Ar1、Ar2、A、B、a和b如说明书中所定义。 该有机发光装置可包括包含该杂环化合物的有机层，因此可具有低驱动电压、高发射效率和长寿命特性。

Heterocyclic compounds represented by the general formula (I): (I) wherein X and Y are different from each other and are halo selected from among chloro, bromo and iodo, CF3SO3-, CH3SO3-, C6H5SO3-, or CH3C6H4SO3-; R1 is an optionally substituted monovalent aliphatic hydrocarbon group having two or more carbon atoms; one of A1 and A2 is-S-,-O-,-Se-or-Te-, while the other is-N=,-P=, or-Si(R2)= (wherein R2 is hydrogen, an optionally substituted monovalent hydrocarbon group, halogen, amino or carbonyl); and one of the two linkages each represented by a solid line and a broken line is a single bond...

The synthesis of newer and more novel molecules has always been a goal for research in organic chemistry. Heterocyclic compounds are those in which the fundamental compound structure contains an element other than carbon. These molecules may also be aromatic, which means they have a distinct odor. The composition of heterocyclic compounds will be discussed in depth in this study. The paper will also go through the synthesis and application methodologies. The pharmaceutical sector makes substantial use of these chemicals. It is largely employed in histamine and serotonin-related medications in ...

the chemistry of heterocyclic compounds thiophene and its derivatives are a good way to achieve details about operating certainproducts. Many products that you buy can be obtained using instruction manuals. These user guides are clearlybuilt to give step-by-step information about how you ought to go ahead in operating certain equipments. Ahandbook is really a user's guide to operating the equipments. Should you loose your best guide or even the productwould not provide an instructions, you can easily obtain one on the net. You can search for the manual of yourchoice online. Here, it is possibl...

A compound of formula (I) or a pharmaceutically acceptable salt, ester or prodrug thereof for use as a pharmaceutical, wherein each of A1, A2, A3, A4 are independently selected from the group N or the group C-R3, where R3 is H or a substituent group C, and wherein at least one of A2 and A4 is N.

PREFACE. CONTRIBUTORS. INTRODUCTION: NOMENCLATURE OF POLYFLUORINATED HETEROCYCLES. PART I SYNTHESIS AND CHEMISTRY OF FLUORINATED HETEROCYCLES. 1 Fluorinated Three-Membered Ring Heterocycles ( David M. Lemal and Sudharsanam Ramanathan). 2 Fluorinated Four-Membered Heterocycles ( Roman B. Larichev and Viacheslav A. Petrov). 3 Fluorinated Five-Membered Nitrogen-Containing Heterocycles ( Kenneth L. Kirk). 4 Fluorinated Five-Membered Heterocycles Containing Oxygen, Sulfur, Selenium, and Phosphorus ( Yuriy Shermolovich). 5 Synthesis of Fluorinated Sugars from Fluorine-Containing Synthons ( Xiao-Long...

Four triatomic heterocyclic compounds were optimized extensively by utilizing Gaussian94 program package at the B3LYP/6-311++G** level. The computed results are in good agreement with the experimental values, which shows that the Density Functional Theory (DFT) method is stable and reliable for optimizations of heterocyclic compounds.Based on this,some thermodynamic parameters and the vibrational frequencies were got and the vibrational analysis was carried out.

Reactivities of Mes -protected 1,3,6-triphosphafuluence and 1,4-diphosphafulrence were studied, such as nucleophilic addition, protonation, CT-complex formation, and chalcogenization.

この20年 来,有 機 リン化 合物 の化 学 は 急激 な 進歩を とげ,数 多 くの化合物 が合成 され,ま た,こ れ を利用す る反応 も多 く報告 され てお り,昨 年 よ り"Phosphorus" とい う隔 月刊行誌(Gordon and Breach Science Publishers)が 創刊 されてい る現状 であ る。一般 に有機 リン化 合 物の化 学 として特徴 をま とめ るこ とは比較 的容 易で あ るが,本 特集の複素環 化合物 としての個有 な反応,ま た 特徴的 な性質 をひろい上げ組織 的にま とめあげ るこ とは 困難で ある。 また,リ ンを含むヘテ ロ環 化合物は,ヘ テ ロ 原子 として リンのみ を含む もの と,酸 素や窒素な どを含 むものなどきわめて多 くの種類が知 られてい る。 とくに 環 内に酸素 を含 む環状 リン酸エ ステル の反応 は深 く研究 されてい るが,ヌ ク レオチ ド類 に代表 され る リン酸エス テルの化 学 として取 り扱 われ広 く紹介 され てい るので, ここで は省略す る。 したがってい ささか断片 的,ま た, 記述 も一つの焦点に しぼってま とめ上 げるこ とはできな か ったが以下2部5章 にわた り,リ ンを含 むヘテ ロ環化 合物 の化学の最近の進歩について述べてみたい...

Pyrolyse de perbromo diphenyle ether (ignifugeant pour matieres plastiques) en dibenzofurannes et dibenzo-p-dioxinnes polybromes

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The interpretation of the significance of the results from X-ray crystallographic analysis in organic chemistry is discussed. It is important to investigate the three-dimensional precise structure for the research on characterization and chemical reactivity. Therefore, structure establishment for the basic molecular units such as azabenzenes is introduced to present its achievement in chemistry involving heterocyclic aromatic compounds, in the first place. In addition, stereochemistry of aromatic amide compounds and investigations on asymmetric transformation are the subjects with respect to X...

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U danasnje doba heterocikli su zbog svojih karakteristika prihvaceni i dominiraju u svim granama medicine, biologije i naravno kemije. Kako pronaci metode sinteze istih koje ce minimalno onecistiti okolis? Odgovor je dan davnih godina istraživanjima Giacoma Ciamiciana koji je otkrio suncevu svjetlost kao jedan od najboljih reagenasa koje „zelena“ kemija posjeduje. Oksazol je heterociklicki spoj sa dva heteroatoma, kisikom i dusikom. Javlja se u velikom broju zanimljivih bioloski aktivnih spojeva, te u bojilima, scintilatorima, itd. S obzirom na dva heteroatoma njegova aromaticnost je narusena,...

Combinatorial chemistry has become an important tool in both drug discovery and chemical biology and its continued success is dependent, in part, on further advances in solid-phase organic synthesis (SPOS). This paper describes recent findings and a useful method for the synthesis of heterocycle and nitrogen heterocycle compounds. © Pesticide Science Society of Japan

The synthesis and chemistry of polycyclic of cage compounds have attracted considerable attention in recent years. The vast majority of the work reported in this area has dealt with carbocylic cage compounds. On the other hand, the synthesis and chemistry of heterocyclic cage compounds have received less attention. Recently, we envisioned that studies on the synthesis and chemistry of heterocyclic cage compounds can greatly expand the scopes and utilities of cage compounds.1 As part of a program that involves the synthesis, chemistry, and application of heterocyclic cage compounds, we report h...

Three methods were explored: sequential transesterification and intermolecular cycloaddition of nitrones 64 with allyl alcohols; use of chiral and geometry-fixed nitrone 84; and selective activation of (Z)-64 by Eu(fod)3.

本発明は、ある種の化合物が、ＭＡＰキナーゼシグナル伝達経路において機能するチロシンおよびセリン／スレオニンキナーゼおよびキナーゼ様タンパク質、例えばＲＡＦキナーゼ、セリン／スレオニンキナーゼを阻害するとの発見に関し、これらの化合物を含む組成物、およびチロシンおよびセリン／スレオニンキナーゼおよびキナーゼ類似物依存性疾患、例えば血管形成、癌および心肥大を処置するためのこれらを使用する方法に関する。 【化１】

Vicarious Nucleophile Substitution of Hydrogen (VNS) is a valuable tool in this synthesis of heterocyclic compounds. Its application too the introduction of a variety of substituents to heteroarenes and to the synthesis of hetocyclic rings, such as indoles or quinolines, covering representative examples of reactions, is reviewed

The present invention provides a kind of new compound, can significantly extend the service life of organic heterocyclic device, and significantly improve its effect, electrochemical stability and thermal stability；And provide a kind of organic heterocyclic device that the compound is included in its organic compound layer.

The present invention provides an excellent life characteristic novel cyclic organic electroluminescent element azine compound. (Substituent B each independently represent a phenyl group having at least one nitrogen carbon atoms, an alkyl group having 1 to 12 carbon, diazaphenylene groups adjacent to the nitrogen atom of carbon, or quinazolinyl).

Nighttime atmospheric processing enhances the formation of brown carbon aerosol (BrC) in biomass burning plumes. Heterocyclic compounds, a group of volatile organic compounds (VOCs) abundant in bio...

In particular there is provided a compound of formula (I) as defined in the present specification p38 MAP kinase inhibitors for use as a medicament for the treatment of inflammatory diseases.

It was discovered in the neoteric developments of heterocyclic compounds that these play a vital role in curative chemistry, and exert anticancer, anti-inflammatory, antifungal, antiallergic, antibacterial,anti-HIV, antiviral,Anti-convulsant, and other biological activities.

Proposed compounds are inhibitors of calcium channel function being especially inhibitor of K v 1 subfamily of potential-overlapping K + -channels and especially inhibitors ofK v 1.5 that associated with super-rapid activating delayed cleaning K +-flow of I kur and can be used in treatment of arrhythmia and IKur -associated diseases.

The present invention provides pharmaceutical compositions comprising compounds of Formula I and methods of treating or preventing one or more conditions that may be regulated or normalized via inhibition of dipeptidyl peptidase IV (DPP-IV).

New heterocyclic compounds of the formula (I) (wherein, R 1, D, W, T, and T has the meanings indicated in claim 1) is a SGK inhibitors, SGK may be used for the treatment of induced diseases and conditions.

The compound is useful as a medicinal ingredient having a CRF antagonistic activity for use in the prevention and/or treatment of a neurological/psychiatric disease, a disease in a terminal organ or the like.

The present invention provides a compound with the unexpected insecticidal activity. A compound of formula (I): [Formula 1] Preferred compounds are, How to spraying the compounds of formula (I), the composition consisting of optionally the second compound and the carrier and this if you are a pest.

Compounds of the present invention as depression, schizophrenia, Alzheimer's disease or attention deficit hyperactivity disorder (ADHD) and other drugs useful for the prophylaxis or treatment.

(57) Abstract: The present invention relates to a process for the production of intermediates useful for preparing the therapeutically active azacyclic or aza bicyclic compounds.

A selected from Formula 1 or Formula 1A compound, its N-oxides and salts, ** ** Formula wherein E is ** ** Formula Y1, Y2 and Y3 in formula 1 form a ring selected from ** ** formula wherein the bond projecting to the left, marked with a * in L-1, L-2 and L-9 is attached to E in formula 1 and the bond projecting to the right, marked with a T, it is connected to G in Formula 1; Y2, X1 and X2 in Formula 1A form a ring selected from ** ** Formula wherein the bond projecting to the left, marked with a * in L-60 and L-64, is attached to E in Formula 1A and the bond projecting to the right, marked wi...

A useful antidepressant compound showing inhibition of 5-HT reuptake is provided, and its application in clinical practice is still under investigation.

The patent application relates to new heterocyclic compounds of the general formula (I), in which R, R1, R2, Q, T, n and p have the definitions elucidated in more detail in the description, to a process for preparing them and to the use of these compounds as medicaments, particularly as aldosterone synthase inhibitors.

A compound represented by the formula (I) or a salt of the compound is a tyrosinkinase inhibitor or a preventive/therapeutic agent for cancers which each contains the compound or a prodrug thereof.

The present invention provides a PDE9 inhibitor compound of formula (I) and pharmaceutically acceptable salts thereof and pharmaceutical compositions containing compounds of formula I and their use in the treatment of neurodegenerative and cognitive disorders such as Alzheimer's disease and schizophrenia.

PURPOSE: To obtain a new nitrogen heterocyclic compd. effective in treating hypertension, congestive heart failure, etc. CONSTITUTION: The nitrogen heterocyclic compd. is a compd. of formula I [where R 1 is H, alkyl, phenyl, etc.; R 2 is H, alkyl or cycloalkyl; R 3 is R 1 , a halogen, alkoxy, amino, etc.; R 4 is H, amino, OH, alkoxy, alkyl, carboxy, CN, NO 2 , phenyl, etc.; R 5 is H; R 6 is H or alkyl; R 7 is H, alkyl, alkoxy, halogen, CN, etc.; X is phenylene or a direct bond; Rz is H, alkyl, alkanoyl or benzoyl; and Z is 1H-tetrazol-5-yl, COOR 8 (R 8 is H, the residue of a physiologically ac...

THE INVENTION RELATES TO THE PREPARATION OF HETEROCYCLIC COMPOUNDS. IT RELATES TO A METHOD OF PREPARATION OF A COMPOUND OF THE GENERAL FORMULA (CF DRAWING IN BOPI) R REPRESENTS OR ATOM HYDROGEN OR GROUP MAY BE sUBSTITUTED alkyl or cycloalkyl, R REPRESENTS A GROUP MAY BE sUBSTITUTED alkyl or cycloalkyl, R EACH AND REGARDLESS R REPRESENTS A GROUP alkyl or cycloalkyl MAY SUBSTITUTE AND EACH R AND R REPRESENTS INDEPENDENT GROUP alkyl, cycloalkyl, alkenyl, alkynyl, aRYL OR optionally substituted aralkyl, INCLUDING THE REACTION OF hYDRAZONE APPROPRIATE WITH A SUITABLE DICARBOXYLATE. PRODUCTS ARE USE...

All that are described are novel heterocyclic compounds of general formulae and (values of radicals are given in invention formula), pharmaceutical compositions containing them and application of said heterocyClic compounds for treatment disorders mediated with MAP kinase cascade.

The author describes those compounds encountered or connected with in his research, including iridoids, indole alkaloids, adamantanes found in nature, and oxyindoles that are correlated with rearrangements.

OIL organic matter is an essential component of fertility of soils, ..... especially the sandy ones. It also accounts for increasing the emission of the greenhouse gases (GHG). Efficient managements of applied organic amendments to soil are required to reduce GHG emission. The current research aimed at investigating the effects of farm yard manure and compost applied at two different rates, i.e., 24 and 48 Mg ha using shallow (0-10 cm) or deep (0-20 cm) tillage operations on improving the physical properties of the studied soil, carbon sequestration in soil and its relation to the wheat and ma...

The compounds of the present invention is useful for diseases such as chronic obstructive pulmonary disease, cancer or the treatment and / or prevention of skin disorders.

All geometric and stereoisomers, tautomers, and the compounds of formula 1 is disclosed containing the N- oxides and salts, [Formula 1] In the formula, E, X, Y, G, Z and Q are as defined in the present disclosure. The compositions containing the compounds of formula 1, and, a method for controlling plant diseases caused by fungal pathogens comprising applying an effective amount of a compound or composition of the present invention is disclosed.

The present invention provides compounds of formula (I) and salts thereof, wherein Ring A is an optionally substituted 5 to 10 membered aromatic ring; R

A review of the literature on the synthesis of heterocycles revealed several that produced significant yields and could be modified for the organic laboratory.