Prolonged lung cancer screening reduced 10-year mortality in the MILD trial: new confirmation of lung cancer screening efficacy
Annals of OncologyPublished 29 March 2019Open access
Ugo Pastorino, Mario Silva, Stefano Sestini, Federica Sabia, Mattia Boeri, Anna Cantarutti
Citations519
SJR quartileQ1
SJR score19.07
SNIP10.48
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveWill appear once the snapshot is generated
MethodsWill appear once the snapshot is generated
PopulationWill appear once the snapshot is generated
Sample sizeWill appear once the snapshot is generated
OutcomesWill appear once the snapshot is generated
ResultsWill appear once the snapshot is generated
LimitationsWill appear once the snapshot is generated
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
The MILD trial provides additional evidence that prolonged screening beyond 5 years can enhance the benefit of early detection and achieve a greater overall and LC mortality reduction compared with NLST trial.
Abstract
NCT02837809.
Keywords
Medicine
New England Journal of MedicineReduced Lung-Cancer Mortality with Low-Dose Computed Tomographic Screening
10,986 Citations2011Denise R Aberle, Amanda M Adams +8 more
Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.
Journal of Clinical OncologyAnalysis of survival by tumor response.
1,089 Citations1983J R Anderson, Kevin C. Cain +1 more
A comparison of survival by response category may be useful descriptively, but such a comparison should not be used for inference concerning treatment effectiveness.
Journal of Clinical OncologyAnalysis of survival by tumor response.
1,003 Citations1986J R Anderson, Robert B. Davis
A comparison of survival by response category may be useful descriptively, but such a comparison should not be used for inference concerning treatment effectiveness.
JAMA Internal MedicineOverdiagnosis in Low-Dose Computed Tomography Screening for Lung Cancer
773 Citations2014Edward F. Patz, Paul F. Pinsky +7 more
More than 18% of all lung cancers detected by LDCT in the NLST seem to be indolent, and overdiagnosis should be considered when describing the risks of LDCT screening for lung cancer.
Journal of Thoracic OncologyBiomarkers in Lung Cancer Screening: Achievements, Promises, and Challenges
577 Citations2018Luis Seijó, Nir Peled +10 more
The present review is an update of the research and development efforts regarding the use of molecular biomarkers in the lung cancer screening setting and proposes some principles to optimize lung cancer biomarker discovery projects.
The LancetEarly lung-cancer detection with spiral CT and positron emission tomography in heavy smokers: 2-year results
455 Citations2003Ugo Pastorino, Massimo Bellomi +7 more
Combined use of low-dose spiral CT and selective PET effectively detects early lung cancer in high-risk individuals in a large cohort of high- risk volunteers.
Journal of Clinical OncologyClinical Utility of a Plasma-Based miRNA Signature Classifier Within Computed Tomography Lung Cancer Screening: A Correlative MILD Trial Study
437 Citations2014Gabriella Sozzi, Mattia Boeri +12 more
This large validation study indicates that MSC has predictive, diagnostic, and prognostic value and could reduce the false-positive rate of LDCT, thus improving the efficacy of lung cancer screening.
European Journal of Cancer PreventionAnnual or biennial CT screening versus observation in heavy smokers
411 Citations2012Ugo Pastorino, Marta Rossi +10 more
There was no evidence of a protective effect of annual or biennial LDCT screening, and a meta-analysis of the four published randomized trials showed similar overall mortality in the LDCT arms compared with the control arm.
American Journal of Respiratory and Critical Care MedicineLong-Term Follow-up Results of the DANTE Trial, a Randomized Study of Lung Cancer Screening with Spiral Computed Tomography
365 Citations2015Maurizio Infante, Silvio Cavuto +22 more
The results of the DANTE (Detection and screening of early lung cancer with Novel imaging TEchnology) trial do not allow us to make a definitive statement about the efficacy of LDCT screening, but underline the importance of obtaining additional data from randomized trials with intervention-free reference arms before the implementation of population screening.
American Journal of Respiratory and Critical Care MedicineResults of the Randomized Danish Lung Cancer Screening Trial with Focus on High-Risk Profiling
341 Citations2015Mathilde Marie Winkler Wille, Asger Dirksen +14 more
Older participants, those with chronic obstructive pulmonary disease, and those with more than 35 pack-years of smoking had a significantly increased risk of death due to lung cancer, with nonsignificantly fewer deaths in the screening group.
ThoraxUK Lung Cancer RCT Pilot Screening Trial: baseline findings from the screening arm provide evidence for the potential implementation of lung cancer screening
331 Citations2015John K. Field, Stephen W. Duffy +24 more
The UKLS pilot trial demonstrated that it is possible to detect lung cancer at an early stage and deliver potentially curative treatment in over 80% of cases and health economic analysis suggests that the intervention would be cost effective.
ThoraxMortality, survival and incidence rates in the ITALUNG randomised lung cancer screening trial
303 Citations2017Euǵenio Paci, Donella Puliti +10 more
The ITALUNG trial outcomes suggest that LDCT screening could reduce LC and overall mortality and the comparison of the number of LC cases diagnosed in the two groups does not show overdiagnosis after an adequate follow-up period.
ThoraxFinal screening round of the NELSON lung cancer screening trial: the effect of a 2.5-year screening interval
263 Citations2016Uraujh Yousaf-Khan, Carlijn van der Aalst +12 more
Results provide results of the fourth screening round after a 2.5-year interval in the Dutch-Belgian Lung Cancer Screening trial (NELSON), which showed the effect of screening was reduced: the interval cancer rate was higher compared with the 1-year and 2-year intervals, and proportion of advanced disease stage in the final round was higher than with the previous rounds.
Thoracic surgery clinics/Thorac. surg. clin.National Comprehensive Cancer Network (NCCN) Clinical Practice Guidelines for Lung Cancer Screening
258 Citations2015Douglas E. Wood
The intent of the NCCN Guidelines is to assist in the decision-making process of individuals involved in cancer care-including physicians, nurses, pharmacists, payers, patients, and their families-with the ultimate goal of advancing patient care in the fight against cancer.
The Lancet OncologyLung cancer incidence and mortality in National Lung Screening Trial participants who underwent low-dose CT prevalence screening: a retrospective cohort analysis of a randomised, multicentre, diagnostic screening trial
178 Citations2016Edward F. Patz, Erin Greco +4 more
Rates of lung cancer in National Lung Screening Trial (NLST) participants who had a negative prevalence (initial) low-dose CT screen were examined to explore whether less frequent screening could be justified in some lower-risk subpopulations.
Journal of Thoracic OncologyRandomized Study on Early Detection of Lung Cancer with MSCT in Germany: Results of the First 3 Years of Follow-up After Randomization
150 Citations2015Nikolaus Becker, Erna Motsch +12 more
Early recall rates were significantly lower in the subsequent screening rounds than in the first one if the MSCT information from the previous screening rounds was available, indicating that screening must be strictly organized to be effective.
European RadiologyComputed tomographic characteristics of interval and post screen carcinomas in lung cancer screening
115 Citations2014Ernst T. Scholten, Nanda Horeweg +5 more
Interval or post-screen carcinomas that were visible in retrospect were mostly due to detection errors of solid nodules, bulla wall thickening or endobronchial lesions.
European RadiologyLow-dose computed tomography for lung cancer screening: comparison of performance between annual and biennial screen
114 Citations2016Nicola Sverzellati, Mario Silva +6 more
The Lancet Respiratory MedicineLung cancer screening: latest developments and unanswered questions
87 Citations2016Carlijn M. van der Aalst, Kevin ten Haaf +1 more
The latest developments in CT lung cancer screening are highlighted and an overview of the main unanswered questions are provided.
JAMA Internal MedicineEstimation of Overdiagnosis of Lung Cancer in Low-Dose Computed Tomography Screening
80 Citations2018Bruno Heleno, Volkert Siersma +1 more
This study analyzes data from the Danish Lung Cancer Screening Trial to determine the amount of overdiagnosis of computed tomography–detected lung cancer.
Journal of Thoracic OncologyLong-Term Active Surveillance of Screening Detected Subsolid Nodules is a Safe Strategy to Reduce Overtreatment
79 Citations2018Mario Silva, Mathias Prokop +9 more
Subjects with SSN in the MILD cohort showed a high risk of developing lung cancer elsewhere in the lung, with only a minority of cases arising from SSN, and never representing the cause of death.
BMJScreening for lung cancer using low dose computed tomography
76 Citations2014Martin C. Tammemägi, Stephen Lam
Sufficient data are available to support the implementation of screening programs at the population level in stages that can be expanded when found to perform well to improve the outcome of patients with lung cancer.
ThoraxRisk stratification based on screening history: the NELSON lung cancer screening study
65 Citations2017Uraujh Yousaf-Khan, Carlijn van der Aalst +10 more
‘Smoked pack-years’ and ‘screening history’ significantly predicted the fourth round test result, providing an opportunity for further risk stratifications of those who undergo lung cancer screening.
Lung CancerBiennial lung cancer screening in Canada with smoking cessation—outcomes and cost-effectiveness
62 Citations2016John R. Goffin, W. Michael Flanagan +5 more
Over 20 years, biennial LDCT screening for lung cancer appears to provide similar benefit in terms of QALYs gained to annual screening and is more cost-effective.
European Journal of Cancer PreventionLung cancer screening with low-dose spiral computed tomography: evidence from a pooled analysis of two Italian randomized trials
51 Citations2016Maurizio Infante, Stefano Sestini +14 more
A patient-level pooled analysis of two Italian randomized controlled trials shows a nonsignificant 11% reduction in overall mortality in individuals undergoing LDCT screening as compared with the control arm.
ThoraxLung cancer risk to personalise annual and biennial follow-up computed tomography screening
39 Citations2018Anton Schreuder, Cornelia Schaefer‐Prokop +4 more
The polynomial model, using both patient characteristics and baseline scan morphology, was significantly superior in assigning participants to 1-year or 2-year screening intervals.
