Global Prevalence of Helicobacter pylori Infection: Systematic Review and Meta-Analysis
GastroenterologyPublished 27 April 2017Open access
James K.Y. Hooi, Wan Ying Lai, Wee Khoon Ng, Michael M.Y. Suen, Fox E. Underwood, Divine Tanyingoh
Citations3,368
SJR quartileQ1
SJR score7.20
SNIP5.04
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveWill appear once the snapshot is generated
MethodsWill appear once the snapshot is generated
PopulationWill appear once the snapshot is generated
Sample sizeWill appear once the snapshot is generated
OutcomesWill appear once the snapshot is generated
ResultsWill appear once the snapshot is generated
LimitationsWill appear once the snapshot is generated
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Large amounts of variation among regions are observed among regions-more than half the world's population is infected, which can be used in development of customized strategies for the global eradication.
Abstract
In a systematic review and meta-analysis to assess the prevalence of H pylori infection worldwide, we observed large amounts of variation among regions-more than half the world's population is infected. These data can be used in development of customized strategies for the global eradication.
Keywords
Medicine
BMJPreferred reporting items for systematic reviews and meta-analyses: the PRISMA statement
83,276 Citations2009David Moher, A. Liberati +3 more
PubMedPreferred reporting items for systematic reviews and meta-analyses: the PRISMA Statement.
45,120 Citations2009David Moher, Alessandro Liberati +2 more
Medical Entomology and ZoologyThe Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomised Studies in Meta-Analyses
17,869 Citations2014George A. Wells
The goal of this project is to develop an instrument providing an easy and convenient tool for quality assessment of nonrandomised studies to be used in a systematic review.
The LancetUNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION
5,500 Citations1984Barry J. Marshall, J.Robin Warren
The bacteria were present in almost all patients with active chronic gastritis, duodenal ulcer, or gastric ulcer and thus may be an important factor in the aetiology of these diseases.
GastroenterologyIncreasing Incidence and Prevalence of the Inflammatory Bowel Diseases With Time, Based on Systematic Review
4,738 Citations2011Natalie A. Molodecky, Ing Shian Soon +9 more
Although there are few epidemiologic data from developing countries, the incidence and prevalence of IBD are increasing with time and in different regions around the world, indicating its emergence as a global disease.
New England Journal of Medicine<i>Helicobacter pylori</i> Infection and the Development of Gastric Cancer
4,407 Citations2001Naomi Uemura, Shiro Okamoto +7 more
Gastric cancer develops in persons infected with H. pylori but not in uninfected persons, and those with histologic findings of severe gastric atrophy, corpus-predominant gastritis, or intestinal metaplasia are at increased risk.
New England Journal of Medicine<i>Helicobacter pylori</i> Infection and the Risk of Gastric Carcinoma
3,878 Citations1991Julie Parsonnet, Gary Friedman +5 more
Infection with H. pylori is associated with an increased risk of gastric adenocarcinoma and may be a cofactor in the pathogenesis of this malignant condition.
GutCurrent concepts in the management of Helicobacter pylori infection: the Maastricht III Consensus Report
2,230 Citations2006Peter Malfertheiner, Françis Mégraud +9 more
H pylori eradication is less effective than proton pump inhibitor (PPI) treatment in preventing ulcer recurrence in long term NSAID users and a test and treat strategy using a non-invasive test is recommended in adult patients with persistent dyspepsia under the age of 45.
GutGastric cancer and <i>Helicobacter pylori</i> : a combined analysis of 12 case control studies nested within prospective cohorts
1,047 Citations2001Helicobacter and Cancer Collaborative Group
The results suggest that 5.9 is the best estimate of the relative risk of non-cardia cancer associated with H pylori infection and that Hpylori does not increase the risk of cardia cancer.
GastroenterologyMeta-analysis of the relationship between Helicobacter pylori seropositivity and gastric cancer
959 Citations1998Jiaqing Huang, Subbaramiah Sridhar +2 more
Meta-analysis of cohort or case-control studies with age- and/or sex-matched controls with raw data on H. pylori infection found the source of heterogeneity between studies was caused by differences in the selection of controls, patient age, and the site and stage of gastric cancer.
The American Journal of GastroenterologyAssociation of Helicobacter Pylori Infection With Gastric Carcinoma: A Meta-Analysis
402 Citations1999Guy D. Eslick, Lynette Lim +3 more
H. pylori infection is associated with a 2-fold increased risk of developing gastric adenocarcinoma, and there was significant heterogeneity among the studies.
The Journal of Infectious DiseasesSeroprevalence and Ethnic Differences in<i>Helicobacter pylori</i>Infection among Adults in the United States
356 Citations2000James E. Everhart, Deanna Kruszon‐Moran +3 more
The seroprevalence of Helicobacter pylori infection was examined in the adult US population and among different ethnic groups and the high prevalence among non-Hispanic blacks and Mexican Americans is partially explained by other factors associated with infection.
World Journal of GastroenterologyHistory of<i>Helicobacter pylori</i>, duodenal ulcer, gastric ulcer and gastric cancer
328 Citations2014David Y. Graham
It is shown that gastric cancer and gastric ulcer were present throughout the 17th to 19th centuries consistent with atrophic gastritis being the predominant pattern, as it proved to be when it could be examined directly in the late 19th century.
The LancetEfficacy, safety, and immunogenicity of an oral recombinant Helicobacter pylori vaccine in children in China: a randomised, double-blind, placebo-controlled, phase 3 trial
290 Citations2015Ming Zeng, Xuhu Mao +20 more
The oral recombinant H pylori vaccine was effective, safe, and immunogenic in H plyori-naive children and follow-up over a longer period is needed to confirm the protection of the vaccine against H pylonori-associated diseases.
American Journal of EpidemiologyIron Deficiency and Helicobacter pylori Infection in the United States
259 Citations2005Víctor M. Cárdenas, Zuber D. Mulla +2 more
In the United States, H. pylori infection was associated with iron deficiency/IDA regardless of the presence or absence of peptic ulcer disease.
Proceedings of the National Academy of SciencesHuman and <i>Helicobacter pylori</i> coevolution shapes the risk of gastric disease
237 Citations2014Nuri Kodaman, Alvaro J. Pazos +15 more
It is concluded that coevolutionary relationships are important determinants of gastric disease risk and that the historical colonization of the Americas continues to influence health in modern American populations.
Gut PathogensSystematic review of time trends in the prevalence of Helicobacter pylori infection in China and the USA
202 Citations2016Péter Nagy, Saga Johansson +1 more
The prevalence of H. pylori infection is most likely decreasing in China, due to a combination of increasing urbanization, which will probably result in a gradual decrease in peptic ulcer and gastric cancer rates in China over time.
The LancetConcomitant, bismuth quadruple, and 14-day triple therapy in the first-line treatment of Helicobacter pylori: a multicentre, open-label, randomised trial
195 Citations2016Jyh‐Ming Liou, Yu-Jen Fang +23 more
Ten-day bismuth quadruple therapy was superior to 14-day triple therapy in the first-line treatment of H pylori in the face of rising prevalence of clarithromycin resistance, but not 10-day concomitant therapy.
PubMedHelicobacter pylori Infection and Gastric Adenocarcinoma.
188 Citations2011Pelayo Correa, M. Blanca Piazuelo
Identification of individuals at high risk for gastric cancer that may enter a surveillance program and intervention during the precancerous process is the most suitable strategy for decreasing mortality due to this malignancy.
Clinical and Diagnostic Laboratory ImmunologyHigh Prevalence of <i>Helicobacter pylori</i> in the Alaska Native Population and Association with Low Serum Ferritin Levels in Young Adults
177 Citations2000Alan J. Parkinson, Benjamin D. Gold +6 more
A significant association between low serum ferritin levels and prevalence of H. pylori-specific IgG was found, particularly for people aged less than 20 years, which could be a factor contributing to the iron deficiency anemia in the Alaska Native population.
The American Journal of GastroenterologyThe Association Between Helicobacter pylori Infection and Early Gastric Cancer: A Meta-Analysis
146 Citations2007Wang Chang-cheng, Yuhong Yuan +1 more
This study indicates that H. pylori infection is strongly associated with early gastric cancer when compared with non-neoplasm controls or advanced Gastric cancer.
Alimentary Pharmacology & Therapeutics<i>Helicobacter pylori</i> eradication reduced the incidence of gastric cancer, especially of the intestinal type
125 Citations2007Ryuta Takenaka, Hiroyuki Okada +10 more
Although Helicobacter pylori infection is closely associated with gastric cancer development, follow‐up studies after H. pylora eradication are still scarce.
European Journal of Gastroenterology & HepatologyThe racial cohort phenomenon: seroepidemiology of Helicobacter pylori infection in a multiracial South-East Asian country
103 Citations2001Khean‐Lee Goh, N Parasakthi
The pattern of infection in a multiracial population in Malaysia points to a ‘racial cohort' phenomenon, with the Malays having consistently low prevalence rates, and the infection appears to be confined to a racial group.
International Journal of CancerExploring the cost‐effectiveness of<i>Helicobacter pylori</i>screening to prevent gastric cancer in China in anticipation of clinical trial results
100 Citations2008Jennifer M. Yeh, Karen M. Kuntz +2 more
Screening young adults for H. pylori could prevent one in every 4 to 6 cases of gastric cancer in China and would be considered cost‐effective using the GDP per capita threshold.
World Journal of Gastroenterology<i>Helicobacter pylori</i>eradication for preventing gastric cancer
95 Citations2014Bin Lü
Journal of Digestive DiseasesAfrican, Asian or Indian enigma, the East Asian <i>Helicobacter pylori</i>: facts or medical myths
84 Citations2009David Y. Graham, Hong Lü +1 more
It is suggested that a better strategy would be to focus on the pathogenesis of underlying histopathologic differences which could also lead to the identification of specific chemoprevention strategies.
HelicobacterIntrafamilial, Preferentially Mother‐to‐Child and Intraspousal, <i>Helicobacter pylori</i> Infection in Japan Determined by Mutilocus Sequence Typing and Random Amplified Polymorphic <scp>DNA</scp> Fingerprinting
81 Citations2015Shin‐ichi Yokota, Mutsuko Konno +6 more
Whether multilocus sequence typing (MLST) was useful for analysis of intrafamilial infection of Helicobacter pylori was examined and the possibility of intraspousal infection was evaluated.
The Medical Journal of AustraliaPrevalence of Helicobacter pylori in Indigenous Western Australians: comparison between urban and remote rural populations
65 Citations2005Helen M. Windsor, Susan D Morrow +4 more
The prevalence of Helicobacter pylori in an urban and a remote rural Western Australian Indigenous community is compared to determine and compare the prevalence of the bacterium in these communities.
International Journal of CancerGastric cancers in Finnish patients after cure of <i>Helicobacter pylori</i> infection: A cohort study
55 Citations2010Timo U. Kosunen, Eero Pukkala +5 more
C cured H. pylori infection led to a significantly decreased incidence of gastric cancers from the sixth follow-up year, and advanced atrophic gastritis would be a plausible contributor to the elevated SIR in elderly Hp– patients.
The Journal of Infectious DiseasesCost‐Effectiveness of a Potential Prophylactic<i>Helicobacter pylori</i>Vaccine in the United States
50 Citations2009Marcia F.T. Rupnow, Alicia H. Chang +3 more
When evaluated with a time horizon beyond 40 years, the use of a prophylactic H. pylori vaccine was cost-effective in the United States, especially with infant vaccination.
Journal of Gastroenterology and HepatologyRacial differences in <i>Helicobacter pylori</i> seroprevalence in Singapore: Correlation with differences in peptic ulcer frequency
39 Citations1997JY KANG, KG YEOH +7 more
Racial differences in peptic ulcer frequency between Chinese and Indians are not explained by the prevalence of H. pylori infection; other environmental or genetic factors may be involved.
