Effects of Exercise Training on Health Status in Patients With Chronic Heart Failure
JAMAPublished 7 April 2009Open access
Kathryn E. Flynn, Ileana L. Piña, David J. Whellan, Li Lin, James A. Blumenthal, Stephen J. Ellis
Citations725
Generate an AI Snapshot to get a quick, structured summary of this paper.
Study Snapshot
ObjectiveWill appear once the snapshot is generated
MethodsWill appear once the snapshot is generated
PopulationWill appear once the snapshot is generated
Sample sizeWill appear once the snapshot is generated
OutcomesWill appear once the snapshot is generated
ResultsWill appear once the snapshot is generated
LimitationsWill appear once the snapshot is generated
A concise AI-generated summary of the paper will appear here once you click Generate AI Snapshot.
TL;DR
Exercise training conferred modest but statistically significant improvements in self-reported health status compared with usual care without training, and Improvements occurred early and persisted over time.
Abstract
clinicaltrials.gov Identifier: NCT00047437.
Keywords
Medicine
JAMAEfficacy and Safety of Exercise Training in Patients With Chronic Heart Failure
2,104 Citations2009Christopher M. O’Connor, David J. Whellan +16 more
Exercise training was associated with modest significant reductions for both all-cause mortality or hospitalization and cardiovascular mortality or heart failure hospitalization, and in key secondary clinical end points.
Journal of the American College of CardiologyDevelopment and evaluation of the Kansas City Cardiomyopathy Questionnaire: a new health status measure for heart failure
1,807 Citations2000C.Patrick Green, Charles Porter +2 more
The Kansas City Cardiomyopathy Questionnaire is a valid, reliable and responsive health status measure for patients with CHF and may serve as a clinically meaningful outcome in cardiovascular research, patient management and quality assessment.
PubMedCombined cardiac resynchronization and implantable cardioversion defibrillation in advanced chronic heart failure: the MIRACLE ICD Trial.
1,620 Citations2003James B. Young, William T Abraham +9 more
Cardiac resynchronization improved quality of life, functional status, and exercise capacity in patients with moderate to severe HF, a wide QRS interval, and life-threatening arrhythmias without proarrhythmia or compromised ICD function.
CirculationRandomized, Controlled Trial of Long-Term Moderate Exercise Training in Chronic Heart Failure
1,096 Citations1999Romualdo Belardinelli, Demetrios Georgiou +2 more
Long-term moderate ET determines a sustained improvement in functional capacity and quality of life in patients with CHF and seems to translate into a favorable outcome.
Archives of General PsychiatrySome Conceptual and Statistical Issues in Analysis of Longitudinal Psychiatric Data
728 Citations1993Robert D. Gibbons
A family of statistical models termed random regression models were used that provide a more realistic approach to analysis of longitudinal psychiatric data and indicated that both person-specific effects and serial correlation play major roles in the longitudinal psychiatric response process.
American Heart JournalMonitoring clinical changes in patients with heart failure: A comparison of methods
547 Citations2005John A. Spertus, Eric D. Peterson +9 more
The Kansas City Cardiomyopathy Questionnaire, followed by the New York Heart Association and the 6-minute walk test, most accurately reflected clinical change in patients with heart failure.
The LancetEffects of physical training in chronic heart failure
437 Citations1990Andrew J.S. Coats
Home-based physical training programmes are feasible even in severe chronic heart failure and have a beneficial effect on exercise tolerance, peak oxygen consumption, and symptoms, and the commonly held belief that rest is the mainstay of treatment of Chronic heart failure should no longer be accepted.
CirculationPrognostic Importance of Emotional Support for Elderly Patients Hospitalized With Heart Failure
346 Citations1998Harlan M. Krumholz, Javed Butler +7 more
Among elderly patients hospitalized with clinical heart failure, the absence of emotional support is a strong, independent predictor of the occurrence of fatal and nonfatal cardiovascular events in the year after admission, and in this cohort, the association is restricted to women.
CirculationDifferential Effects of β-Blockers in Patients With Heart Failure
332 Citations2000Marco Metra, Raffaele Giubbini +4 more
C carvedilol produced greater decreases in mean pulmonary artery pressure and pulmonary wedge pressure, both at rest and during exercise, than metoprolol after 13 to 15 months of treatment, and showed larger increases in left ventricular ejection fraction at rest.
American Heart JournalEffects of exercise training in patients with heart failure: The Exercise Rehabilitation Trial (EXERT)
324 Citations2002Robert S. McKelvie, Koon Teo +6 more
Exercise training improves peak oxygen uptake and strength during supervised training in patients with heart failure, suggesting that some supervision is required for these patients over the final 9 months of the study.
PubMedQuality of life in patients with advanced heart failure.
316 Citations1992Kathleen Dracup, J A Walden +2 more
It is suggested that interventions to improve the quality of life of patients with advanced heart failure need to be targeted at reducing depression and hostility and increasing daily activity levels.
Cochrane Database of Systematic ReviewsExercise based rehabilitation for heart failure
243 Citations2004Karen Rees, Rod Taylor +3 more
American Heart JournalHeart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing (HF-ACTION): Design and rationale
234 Citations2007David J. Whellan, Christopher M. O’Connor +13 more
The HF-ACTION trial is designed to definitively assess the effect of exercise training on the clinically relevant end points of mortality, hospitalization, and quality of life in patients with heart failure.
Annals of Internal MedicineExercise Training in Patients with Heart Failure A Randomized, Controlled Trial
233 Citations1996Steven J. Keteyian, Arlene B. Levine +7 more
The role of exercise training in the treatment of heart failure remains a paradox, because exercise intolerance is a characteristic finding in patients with this condition and the mechanisms by which this improvement occurs are uncertain.
The American Journal of CardiologyPrognostic usefulness of the six-minute walk in patients with advanced congestive heart failure secondary to ischemic or nonischemic cardiomyopathy
185 Citations2001Monica Shah, Vic Hasselblad +5 more
Heart & LungHome-based exercise improves functional performance and quality of life in women with diastolic heart failure
180 Citations2004Rebecca Gary, Carla A. Sueta +6 more
Home-based, low-to-moderate intensity exercise, in addition to education, is an effective strategy for improving the functional capacity and quality of life in women with DHF.
American Heart JournalEffects of exercise training on chronotropic incompetence in patients with heart failure
158 Citations1999Steven J. Keteyian, Clinton A. Brawner +5 more
Exercise training results in an increase in peak heart rate and partial reversal of chronotropic incompetence among patients with stable heart failure, which contribute, in part, to the exercise training-induced increase in exercise capacity that occurs in these patients.
Journal of the American College of CardiologyPredictors of the onset of depressive symptoms in patients with heart failure
156 Citations2004Edward P. Havranek, John A. Spertus +3 more
Social factors and health status are predictive of the development of depression in outpatients with heart failure and Clinicians should be aware of which patients are at risk for theDevelopment of depression so that these patients may be targeted for screening and potentially for psychosocial intervention.
American Heart JournalClinical predictors and timing of New York Heart Association class improvement with cardiac resynchronization therapy in patients with advanced chronic heart failure: Results from the Multicenter InSync Randomized Clinical Evaluation (MIRACLE) and Multicenter InSync ICD Randomized Clinical Evaluation (MIRACLE-ICD) trials
110 Citations2006Luís A. Pires, William T. Abraham +2 more
Several factors predicted CRT response and timing, but given their modest predictive accuracy, comparable for both studies, additional methods for selecting candidates most likely to benefit from CRT are needed.
Heart Failure ReviewsExercise training in patients with heart failure: clinical outcomes, safety, and indications
107 Citations2007Robert S. McKelvie
The effects of exerciseTraining on clinical outcomes and addressing the safety of exercise training and the indications for training in HF patients are reviewed.
Journal of Consulting and Clinical PsychologyA strategy to use soft data effectively in randomized controlled clinical trials.
97 Citations1989Helena C. Kraemer, Sue Thiemann
It is shown that using an intensive design and the slope of response on time as the outcome measure maximizes sample retention and decreases within-group variability, thus (c) maximizing the power of test procedures without requiring increased sample sizes.
Journal of Cardiopulmonary RehabilitationRandomized, Controlled, Trial of Long-Term Moderate Exercise Training in Chronic Heart Failure: Effects on Functional Capacity, Quality of Life and Clinical Outcome
81 Citations1999Romualdo Belardinelli, Demetrios Georgiou +2 more
Australian Journal of PhysiotherapyHome-based exercise increases exercise capacity but not quality of life in people with chronic heart failure: a systematic review
74 Citations2008Chen-Lin Chien, Chi‐Ming Lee +3 more
Home-based exercise increased exercise capacity safely but did not improve quality of life in patients with chronic heart failure, and could therefore be used to improve the management of people with Chronic heart failure who do not have access to hospital-based Exercise.
Coronary Artery DiseaseExercise training in elderly patients with chronic heart failure
50 Citations1998Robert P. Wielenga, I.A. Huisveld +5 more
Exercise training is equally effective in patients aged younger than and older than 65 years, and quality of life aspects were evaluated with the help of the Heart Patients Psychological Questionnaire and a single-question Self Awareness of General Well-Being test.
Coronary Artery DiseaseExercise training in elderly patients with chronic heart failure
4 Citations1999Robert P. Wielenga, I.A. Huisveld +5 more